Name: HeLa Cell Volume Growth & Cell Transition
Creator: Kaggle
License: https://creativecommons.org/publicdomain/zero/1.0/

About this Dataset

HeLa Cell Volume Growth & Cell Transition

HeLa Cell Volume Growth and Cell Cycle Transition

Variation, Measurement, and Additive Noise

By [source]

About this dataset

This dataset provides invaluable insights into the growth and progression of synchronous HeLa cells during cell cycle phase transitions. It contains measurements of single-cell volume growth trajectories and the timing of cell cycle phase transitions, such as beginning and end times of cytokinesis and mitotic cell rounding, within over 1600 cells. By tracing changes in individual volume values, we can identify additive noise in volume growth - continuous fluctuations in volume steps that are otherwise difficult to detect. Furthermore, using a mathematical model to depict noise level as it fluctuates throughout the experiment's duration, we can further track its effects on overall growth patterns. This dataset offers an insight into how random fluctuations may impact cellular behavior across cellular lineages over time. With this data at hand, researchers have a great resource for understanding the intricacies of each individual cell's behavior and gaining a better picture of how complex biological systems work at the single-cell level

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Research Ideas

Studying and understanding the effect of additive noise on single-cell growth trajectories and its implications for cell division and development.

Investigating the impact of environmental and physiological conditions which can lead to different levels of variations in the volume growths of asynchronous HeLa cells.

Analyzing how different types of environmental stimuli affect additive noise at different stages during a single-cell cycle, providing insights into cellular responses to external input

Acknowledgements

If you use this dataset in your research, please credit the original authors.
Data Source

License

License: CC0 1.0 Universal (CC0 1.0) - Public Domain Dedication
No Copyright - You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission. See Other Information.

Columns

File: All4Exp_table.csv

Column name	Description
lineage	Unique identifier for each cell lineage. (String)
number_in_lineage	Number of cells within that particular lineage. (Integer)
vstart	Volume at start of experiment. (Float)
tstart	Time at start of experiment. (Float)
tmitosis_os	Time at onset mitosis. (Float)
vmitosis_os	Volume at onset mitosis. (Float)
tg1	Time at onset G1/S transition. (Float)
vg1	Volume at onset G1/S transition. (Float)
vstartMed	Median volume of the cell. (Float)
vg1Med	Median volume at onset G1/S transition. (Float)
vmitosis_osMed	Median volume of the cell. (Float)
date	Date of experiment. (String)

File: All4Exp_df.csv

Column name	Description
date	Date of experiment. (String)
Frame	Frame number of the cell. (Integer)
Volume2	Volume of the cell at the start of the experiment. (Float)
Volume4	Volume of the cell at the end of the experiment. (Float)
dvdt	Rate of change in volume over time. (Float)
t1	Time of onset of cytokinesis. (Float)
t2	Time of onset of hgeminin expression. (Float)
t3	Time of onset of mitotic cell rounding. (Float)
dqdt	Rate of additive noise over time. (Float)

Acknowledgements

If you use this dataset in your research, please credit the original authors.
If you use this dataset in your research, please credit .

Tables

All4exp Df

@kaggle.thedevastator_hela_cell_volume_growth_and_cell_cycle_transitio.all4exp_df

3.66 MB
108,468 rows
10 columns

CREATE TABLE all4exp_df (
  "frame" BIGINT,
  "volume2" DOUBLE,
  "index2" BIGINT,
  "volume4" DOUBLE,
  "dvdt" DOUBLE,
  "t1" DOUBLE,
  "t2" DOUBLE,
  "t3" DOUBLE,
  "dqdt" DOUBLE,
  "date" BIGINT
);

All4exp Table

@kaggle.thedevastator_hela_cell_volume_growth_and_cell_cycle_transitio.all4exp_table

69.43 kB
1,699 rows
13 columns

CREATE TABLE all4exp_table (
  "lineage" BIGINT,
  "number_in_lineage" BIGINT,
  "vstart" DOUBLE,
  "tstart" DOUBLE,
  "tmitosis_os" DOUBLE,
  "vmitosis_os" DOUBLE,
  "tg1" DOUBLE,
  "vg1" DOUBLE,
  "index2" BIGINT,
  "vstartmed" DOUBLE,
  "vg1med" DOUBLE,
  "vmitosis_osmed" DOUBLE,
  "date" BIGINT
);