Variation, Measurement, and Additive Noise
Dataset Description
HeLa Cell Volume Growth and Cell Cycle Transition
Variation, Measurement, and Additive Noise
By [source]
About this dataset
This dataset provides invaluable insights into the growth and progression of synchronous HeLa cells during cell cycle phase transitions. It contains measurements of single-cell volume growth trajectories and the timing of cell cycle phase transitions, such as beginning and end times of cytokinesis and mitotic cell rounding, within over 1600 cells. By tracing changes in individual volume values, we can identify additive noise in volume growth - continuous fluctuations in volume steps that are otherwise difficult to detect. Furthermore, using a mathematical model to depict noise level as it fluctuates throughout the experiment's duration, we can further track its effects on overall growth patterns. This dataset offers an insight into how random fluctuations may impact cellular behavior across cellular lineages over time. With this data at hand, researchers have a great resource for understanding the intricacies of each individual cell's behavior and gaining a better picture of how complex biological systems work at the single-cell level
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Research Ideas
- Studying and understanding the effect of additive noise on single-cell growth trajectories and its implications for cell division and development.
- Investigating the impact of environmental and physiological conditions which can lead to different levels of variations in the volume growths of asynchronous HeLa cells.
- Analyzing how different types of environmental stimuli affect additive noise at different stages during a single-cell cycle, providing insights into cellular responses to external input
Acknowledgements
If you use this dataset in your research, please credit the original authors.
Data Source
License
License: CC0 1.0 Universal (CC0 1.0) - Public Domain Dedication
No Copyright - You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission. See Other Information.
Columns
File: All4Exp_table.csv
| Column name | Description |
|---|---|
| lineage | Unique identifier for each cell lineage. (String) |
| number_in_lineage | Number of cells within that particular lineage. (Integer) |
| vstart | Volume at start of experiment. (Float) |
| tstart | Time at start of experiment. (Float) |
| tmitosis_os | Time at onset mitosis. (Float) |
| vmitosis_os | Volume at onset mitosis. (Float) |
| tg1 | Time at onset G1/S transition. (Float) |
| vg1 | Volume at onset G1/S transition. (Float) |
| vstartMed | Median volume of the cell. (Float) |
| vg1Med | Median volume at onset G1/S transition. (Float) |
| vmitosis_osMed | Median volume of the cell. (Float) |
| date | Date of experiment. (String) |
File: All4Exp_df.csv
| Column name | Description |
|---|---|
| date | Date of experiment. (String) |
| Frame | Frame number of the cell. (Integer) |
| Volume2 | Volume of the cell at the start of the experiment. (Float) |
| Volume4 | Volume of the cell at the end of the experiment. (Float) |
| dvdt | Rate of change in volume over time. (Float) |
| t1 | Time of onset of cytokinesis. (Float) |
| t2 | Time of onset of hgeminin expression. (Float) |
| t3 | Time of onset of mitotic cell rounding. (Float) |
| dqdt | Rate of additive noise over time. (Float) |
Acknowledgements
If you use this dataset in your research, please credit the original authors.
If you use this dataset in your research, please credit .
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